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BESPOKE IO: Study of ctDNA Guided Immunotherapy

Sponsor: Natera, Inc.

Protocol 20-043-NCP. A clinical trial evaluating the Natera SIGNATERA personalized molecular residual disease test for patients with advanced/unresectable non-small cell lung cancer, colorectal cancer, or melanoma planning to receive treatment with a PD-1, PD-L1, or CTLA-4 targeting immune checkpoint inhibitor without concomitant chemotherapy.

SIGNATERA is a blood test that measures circulating tumor DNA (ctDNA) to evaluate patient response/progression based on changes in ctDNA quantity.

The primary objective of the study is to, "examine the impact of SIGNATERA on clinical decision-making regarding continuation, discontinuation, escalation, or de-escalation of immunotherapy along with standard clinical assessment and care."

For more information please contact the research department at: 631-675-5075